Pharmacotherapy: A Pathophysiologic Approach
8th edition

By: Joseph T. DiPiro,
Robert L. Talbert,
Gary C. Yee,
Gary R. Matzke,
Barbara G. Wells,
L. Michael Posey

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About the Authors

Dr. Joseph T. DiPiro

Dr. Joseph T. DiPiro is Executive Dean of the South Carolina College of Pharmacy. Until recently Dr. DiPiro was Panoz Professor of Pharmacy at the University of Georgia College of Pharmacy, Clinical Professor of Surgery at the Medical College of Georgia, Assistant Dean for the College of Pharmacy and the School of Medicine at the Medical College of Georgia, and Head, Department of Clinical and Administrative Pharmacy. He received his BS in pharmacy from the University of Connecticut and Doctor of Pharmacy from the University of Kentucky. He served a residency at the University of Kentucky Medical Center and a fellowship in Clinical Immunology at Johns Hopkins University.

Dr. DiPiro is the Editor of The American Journal of Pharmaceutical Education. He has published over 120 refereed papers in academic and professional journals, mainly related to antibiotics, drug use in surgery, various issues in pharmacy practice, and pharmacy education. His papers have appeared in Antimicrobial Agents and Chemotherapy, Pharmacotherapy, Critical Care Medicine, JAMA, Annals of Surgery, Archives of Surgery, American Journal of Surgery, Journal of Pharmacology and Experimental Therapeutics, and Surgical Infections. He is the senior editor for Pharmacotherapy: A Pathophysiologic Approach, now in its 5th edition. He is also the author of Concepts in Clinical Pharmacokinetics and Editor of the Encyclopedia of Clinical Pharmacy. He serves on the editorial boards of Pharmacotherapy, American Surgeon, and Medscape Pharmacy.

Dr. DiPiro is a President-Elect of the American College of Clinical Pharmacy. He is also a Fellow of the College and has served on the Research Institute Board of Trustees. He has been a member of the Surgical Infection Society Therapeutic Agents Committee and the American Society of Health-System Pharmacists, having served on the Commission on Therapeutics and the Task Force on Science. In 2002, the American Association of Colleges of Pharmacy selected Dr. DiPiro for the Robert K. Chalmers Distinguished Educator Award. He has also received the Russell R. Miller Literature Award and the Education Award from the American College of Clinical Pharmacy, the Award for Sustained Contributions to the Literature from the American Society of Health-System Pharmacists.

On the personal side, Dr. DiPiro was born near New Haven, CT and he is married with three children. His wife is also a pharmacist. He is a marathon runner and recently completed the Kiawah Island Marathon in 3:13. He also enjoys hiking and camping - particularly above tree line. He is a long-time soccer coach.


Robert L. Talbert

Robert L. Talbert, PharmD, FCCP, BCPS Professor, College of Pharmacy, University of Texas at Austin; Professor, Departments of Medicine and Pharmacology, University of Texas Health Science Center, San Antonio, TX

Dr. Talbert is Professor of Pharmacy, College of Pharmacy with the University of Texas at Austin and Head, Division of Pharmacotherapy. He holds appointments as Professor of Medicine and Pharmacology at the University of Texas Health Science Center in San Antonio. He received his Bachelor of Science in Pharmacy (1971) and Doctor of Pharmacy (1974) degrees from the University of Kentucky and completed a residency at the A.B. Chandler Medical Center in Lexington, Ky. under the preceptorship of Dr. Paul Parker. Dr. Talbert has authored more than 100 scientific and professional articles and book chapters and is one of the editors of Pharmacotherapy: A Pathophysiology Approach, now in the fifth edition. He has been the preceptor for more than 30 specialty practice residents and five clinical sciences fellows.

Dr. Talbert has served American Society of Hospital Pharmacists as Chair of the Special Interest Group in Adult Medicine and as a member of the Commission on Therapeutics. He has served as Chair of the Section of Pharmacy Practice for the American Association of Colleges of Pharmacy. He was Chairman, Research Institute, American College of Clinical Pharmacy August 1993 - August 1994. Dr. Talbert has served as a member of the Specialty Council on Pharmacotherapy of the Board of Pharmaceutical Specialties.. He is Past-President of the American College of Clinical Pharmacy (1992-1993) He has been a member of the Advisory Panel on Cardiovascular and Renal Drugs, The United States Pharmacopeial Convention (1992-1995) and was elected (1986) Fellow of the American College of Clinical Pharmacy (FCCP). He is a Board Certified Pharmacotherapy Specialist (Board of Pharmaceutical Specialties) and member of the Board of Pharmaceutical Specialties.

He is responsible for didactic and clerkship teaching of baccalaureate and Pharm. D. students and supervises their activities on the Medicine Service at University Hospital in San Antonio. Dr. Talbert is a member of the Drug Usage Committee and the Cardiovascular Subcommittee of the Pharmacy and Therapeutics Committee for University Hospital.

Dr. Talbert was born in Benham in eastern Kentucky. He has two children, Marcus and Melissa who have made him proud in everything they do. He has engaged in soaring (flying a glider, no engine=no guts, no glory). He likes to relax at a lake home while boating, fishing and reading.


Gary C. Yee

Gary C. Yee, PharmD, FCCP Professor and Chair, Department of Pharmacy Practice, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE

Dr. Gary Yee is Professor and Chair, Department of Pharmacy Practice, College of Pharmacy, University of Nebraska Medical Center in Omaha, Nebraska. He is the second of five children and was born and raised in Seattle, Washington. He completed his Bachelor of Science in Pharmacy at the University of Washington, his Doctor of Pharmacy at the Philadelphia College of Pharmacy and Science, and post-doctoral training at St. Jude Children's Research Hospital. Before accepting his current position, he held positions at the Fred Hutchinson Cancer Research Center and the University of Florida.

Dr. Yee has been involved in oncology practice, education, and research for more than 25 years. He first became interested in oncology while working in a research laboratory at the University of Washington. The focus of that laboratory's research program was the biochemical pharmacology of novel antitumor agents that exerted its antineoplastic activity by depleting amino acids (e.g. asparagine).

Dr. Yee has published more than 100 research articles, reviews, or book chapters, and his research findings have been published in several prominent medical journals, including the New England Journal of Medicine and the Lancet. He serves on the editorial boards of several journals and newsletters and is a member of advisory boards for or consultant to several pharmaceutical or biotechnology companies. He has given numerous continuing education and research presentations at local, regional, national, and international meetings.

Dr. Yee is married to Esther, and they have five children. In his spare time, he enjoys spending time with his wife and family, fixing things around the house, woodworking, and tennis. He also enjoys a good game of chess (he was one of the top high school chess players in the state of Washington). He does not like golf, bad Chinese food, and weak coffee (after all, he is from Seattle!).


Gary R. Matzke

Gary R. Matzke, PharmD, FCP, FCCP Professor and Vice Chair, Department of Pharmacy and Therapeutics, School of Pharmacy; Professor of Medicine, Renal-Electrolyte Division, School of Medicine, University of Pittsburgh, Pittsburgh, PA

Gary R. Matzke, PharmD, FCP, FCCP has served as a Health Policy Fellow for Senator Judd Gregg for almost two year while the Senator has been Chairman of the U.S. Senate Committee on Health, Education, Labor and Pensions (2003-2004) and the U.S. Senate Budget Committee (2005). His Congressional Science Fellowships have been sponsored by the American Association of Colleges of Pharmacy and American Association for the Advancement of Science. During this time he has been responsible for a multiplicity of issues including; Pharmaceutical compounding, Importation of prescription drugs, Regulation of Internet Pharmacy activities, Clinical trials registry and access to clinical trial results, and health professions education. He also served as one of the staff group leaders for the Senate Republican Task Force on Health Care Costs and the Uninsured.

He also has held since 1991 an academic appointment as Professor of Pharmacy and Therapeutics in the School of Pharmacy and Professor of Medicine, Renal and Electrolyte Division, Department of Medicine of the University of Pittsburgh. The focus of most of his academic career has been on the development of new knowledge regarding the pharmacokinetics, efficacy and safety of medications in patients. In 2002 he refocused his career on the premis that the major battle in healthcare lies in health policy and public education efforts such as health promotion and disease prevention. This sincere desire to contribute to improvements in the quality of healthcare of Americans motivated him to commit the remaining years of his career to healthcare and public health policy advocacy.

Gary was born in Sturgeon Bay, Wisconsin where he attended elementary and high school. During his sophomore year in high school he began to work in a community pharmacy. The contributions that the father and son pharmacist owner team had upon the community convinced him to pursue pharmacy as his career. He received his baccalaureate pharmacy degree from the University of Wisconsin, School of Pharmacy in 1973 and his doctor of pharmacy degree from the University of Minnesota, College of Pharmacy in 1977. His initial academic appointment was as an Assistant Professor at Wayne State University. In the fall of 1980 he joined the faculty of the University of Minnesota, College of Pharmacy and was promoted to full Professor in 1987. From 1989 to 1991 he was Vice Chair and Professor of the Division of Pharmacy Practice at the University of North Carolina-Chapel Hill School of Pharmacy. He joined the faculty of the Schools of Pharmacy and Medicine of the University of Pittsburgh in the fall of 1991 where he has served as Director, Clinical Pharmaceutical Sciences Graduate Program, Co-Director, Clinical Research Training Program, and a member of the Center for Clinical Pharmacology and Center for Research in Health Care, of the Schools of Pharmacy and Medicine of the University of Pittsburgh. .

Dr. Matzke's clinical therapeutic research interests/expertise include development of drug therapy individualization strategies for patients with acute and chronic renal and hepatic insufficiency. The results of pharmacokinetic studies he has directed have provided the scientific basis for FDA labeling for drug dosing for over 25 medications. The focus of his most current clinical investigations include characterization of the regulation of cytochrome P450 mediated metabolism, quantification of the impact of peritoneal and hemodialysis on drug disposition and dynamics, and quantification of the influence of disease and drug therapy on renal hemodynamics including anionic, cationic and PgP mediated tubular transport.

Dr. Matzke is committed to the education/training of future clinical pharmacists and researchers. His academic/educational commitments include serving as course director or coordinator of graduate courses such as; clinical trial design, clinical trial implementation, clinical pharmacokinetics and disease and drug effects on pharmacokinetics and dynamics. He also has coordinates the renal pathophysiology and pharmacotherapeutics course and clinical pharmacokinetics course in the professional curriculum. He has also served as the principal investigator on several multicenter pharmacotherapeutic educational grants including: the American Society of Health System Pharmacists Clinical Pharmacy Dialysis Traineeship and the University of Pittsburgh Nephrology Pharmaceutical Care Preceptorship. During his career has mentored 14 post-doctoral fellows and three PhD clinical scientists. He is an elected fellow of American College of Clinical Pharmacology and American College of Clinical Pharmacy.

Dr. Matzke has published over 152 peer reviewed manuscripts and 45 book chapters dealing with renal pharmacotherapy and pharmacokinetics. He also has edited 10 books including five editions of Pharmacotherapy: A Pathophysiological Approach He is manuscript reviewer for several prestigious pharmacy and medical journals and has served on the Editorial Board of the Annals of Pharmacotherapy, the International Journal of Antimicrobial Agents, Antimicrobial Agents and Chemotherapy, and the American Journal of Kidney Disease. In recognition of these contributions to the profession he received the Russell R. Miller award from the ACCP Pharmacy in 1995 and the ASHP Foundation award for sustained contribution to the Literature of Pharmacy in 2000.

Gary has been married to his wife Cindy, who is also a pharmacist for 25 years and they have six children; three currently in college and two still at home in sixth grade. They enjoy traveling and have had the opportunity to visit almost every state and Europe and Asia several times. On the home front Gary enjoys yard work, golfing, and running and is active in his church. He has completed several marathons during the last few years and God willing will continue the tradition.


Barbara G. Wells

Barbara G. Wells, PharmD, FASHP, FCCP, BCPP Dean and Professor, School of Pharmacy, University of Mississippi, University, MS

Dr. Wells is Dean and Professor at The University of Mississippi School of Pharmacy and Executive Director of the Research Institute of Pharmaceutical Sciences. She earned her B.S.Ph. and Pharm.D. degrees at the University of Tennessee and completed a residency in psychiatric pharmacy at the University of Tennessee and Memphis Mental Health Institute. Dr. Wells was on the faculty at her alma mater for thirteen years, and served as Vice Chairman of the Department of Clinical Pharmacy and Director of Mental Health Pharmacy Programs. Subsequently, she served Samford University School of Pharmacy as Chairman of the Department of Pharmacy Practice and Idaho State University as Dean of the College of Pharmacy.

Dr. Wells has previously served as President and Chair of the Board of Directors of the American Association of Colleges of Pharmacy (AACP), member of the Board of Directors of the American Foundation for Pharmaceutical Education, Vice Chair of the Commission on Credentialing of the American Society of Health-System Pharmacists (ASHP), Chair of the Council of Deans of AACP, Chair of the Section of Teachers of Pharmacy Practice of AACP, Chair of the Board of Pharmaceutical Specialties (BPS), and member of the Specialty Council on Psychiatric Pharmacy within BPS. She is currently President and chair of the Board of Regents of the American College of Clinical Pharmacy (ACCP), member of the NIH Advisory Committee on Research on Women's Health, member of the Psychopharmacologic Drugs Advisory Panel of the FDA, and a fellow of ACCP and ASHP.

Dr. Wells, whose primary instructional interests are in psychiatric therapeutics, has received five teaching awards. She is a recipient of the Robert G. Leonard Lecture Award from the University of Texas College of Pharmacy and the Texas Society of Health-System Pharmacists, the Judith Saklad Memorial Lecture Award from the College of Psychiatric and Neurologic Pharmacists, the Clinical Pharmacotherapeutic Practice Award from the American Pharmaceutical Association, and the Education Award from ACCP. She is a Distinguished Practitioner of the National Academy of Practice of Pharmacy, National Academies of Practice. Her research interests focus on clinical management of schizophrenia, depression and anxiety disorders. She is a scientific editor of Pharmacotherapy and an editor of Pharmacotherapy: A Pathophysiologic Approach, The Pharmacotherapy Handbook, and Pharmacotherapy Essentials.

Dr. Wells was born in Lake Charles Louisiana, but spent most of her adult life in Memphis, Tennessee. She is a third generation pharmacist; her husband, Richard, and her brother, Tom, are also pharmacists. She has two children and three grandchildren. Her main hobby is getting away for a leisurely or working weekend to Pickwick Lake to spend time on their houseboat, which is named "Euphoria."


L. Michael Posey

L. Michael Posey, BS Pharm President, PENS Pharmacy Editorial & News Services, Athens, GA

L. Michael Posey is celebrating a quarter century in pharmacy journalism and publishing during 2005. Since beginning in 1980 as an assistant editor at the American Society of Hospital (now Health-System) Pharmacists, Posey has written or edited several journals, newsletters, newspapers, and books, all directed at meeting the informational and educational needs of pharmacists, student pharmacists, and pharmacy technicians.

One of the founding editors of Pharmacotherapy textbook, Michael edited 55 of the 110 chapters in the first edition. He continues to work hard with the other editors to make sure that this book remains an important resource for pharmacists, student pharmacists, and other health professionals.

Within the American Pharmacists Association, Posey is Editor of JAPhA and the APhA DrugInfoLine and Clinical Editor of Pharmacy Today. He writes or edits the daily clinical news stories on APhA's pharmacist.com Web site, and he writes a daily e-mail newsletter for pharmacy, the PNN Pharmacotherapy Line, content from which is featured on the pharmacotherapyonline.com Web site.

Posey also was the founding editor of The Consultant Pharmacist. For that and 12 years of service as editor of the journal, ASCP honored him with the George F. Archambault Award, its highest honor, in 2000.

Born in Albany, Ga., and raised in the agricultural town of Cordele, Ga., Michael is the youngest of three children. His interests include reading, travel, photography, and wines.